Hydroxypropyl cellulose can be divided into low-substituted hydroxypropyl cellulose (L-HPC) and high-substituted hydroxypropyl cellulose (H-HPC).
Highly substituted hydroxypropyl cellulose properties:
1. It is soluble in water and various organic solvents at room temperature. Such as: anhydrous methanol, ethanol, isopropanol, propylene glycol, dichloromethane, but also soluble in acetone, chloroform, toluene and cellosolve, the solution is transparent.
2, H-HPC is a good thermoplastic material, has excellent film forming properties, the film formation is very tough, the gloss is good, and the elasticity is sufficient. The ash content is extremely low, which makes the product have excellent adhesion. It is very stable as an emulsion thickening and has good dispersibility.
3. H-HPC itself has no pharmacological effects, is non-toxic, and is harmless to the physiology.
4. H-HPC is chemically inert and difficult to chemically react with other substances.
5. The distribution of substituents is relatively uniform and sufficient, and H-HPC is strong in antibacterial.
6. The equilibrium moisture content is low.
7. Because it is non-ionic, it does not gel in acidic solution and shows excellent stability in a wide range of pH values.
8. The concentrated liquid of H-HPC can form a normally oriented liquid crystal.
9. The H-HPC aqueous solution has a surface active effect.
10. The aqueous solution is raised and lowered with temperature, and has undergone a reversible process of gelation and dissolution.
Low-substituted hydroxypropyl cellulose properties:
1. Properties: Low-substituted hydroxypropyl cellulose is dissolved in water into a clear or slightly turbid colloidal solution; it is insoluble in ethanol, acetone or ether. 2, compatibility changes: low-substituted hydroxypropyl cellulose can not be compatible with other high-concentration electrolytes, or cause "salting out". Dissolved low-substituted hydroxypropylcellulose has certain contraindications with phenol derivatives such as methyl and propyl-p-hydroxybenzoate.
Low-substituted hydroxypropyl cellulose (L-HPC) is mainly used as a tablet disintegrating agent and a binder. Low-substituted hydroxypropyl cellulose (L-HPC) is used as a binder and a disintegrant is characterized by easy press molding. It has strong applicability, especially for films that are not easy to form, plastic and brittle. Adding low-substituted hydroxypropyl cellulose (L-HPC) can improve the hardness and appearance of the tablet and also make the tablet disintegrate quickly. Even if the hardness of the film reaches 13kg, the disintegration only takes ten minutes to improve the intrinsic quality of the film and improve the curative effect; the long-term storage disintegration degree of the tablet made with low-substituted hydroxypropyl cellulose (L-HPC) Not affected.
For tablet adhesive, 5~20% is usually added during wet granulation, 5~20% when the powder is directly compressed, used as tablet disintegrating agent, the dosage is 2~10%, generally 5%, and the addition is Plus, depending on the specific prescription.
Low-substituted hydroxypropyl cellulose (L-HPC) can also be used as a food additive in the food industry as an emulsifier, stabilizer, suspending agent, thickener, film-forming agent for beverages, cakes, jams, etc. Manufacturing.
Low-substituted hydroxypropyl cellulose (L-HPC) is also used in the chemical industry for the manufacture of cosmetics such as creams, shampoos, and lotions.